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Most patients, including P4 and to a lesser extent P3, were born with a severe and recognizable facial gestalt, including prominent and protuberant eyes with puffy, edematous eyelids and excessive periorbital skin, large fontanels and/or wide cranial sutures, a hypoplastic chin, and blue or gray discoloration of the sclerae ( n = 12)

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Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist (Aib-His-D-2-Nal-D-Phe-Lys-NH2), CAS 170851-70-4, molecular weight 711.9 Da

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